This medicine is contra-indicated in case of: Hypersensitivity to gliclazide or to any of the excipients listed in Description, other sulfonylurea, sulfonamides; Type 1 diabetes; Diabetic pre-coma and coma, diabetic keto-acidosis; Severe renal or hepatic insufficiency: in these cases the use of insulin is recommended; Treatment with miconazole (see Interactions); Lactation (see Use in Pregnancy & Lactation).